EA-3834

EA-3834
Identifiers
	IUPAC name (1-methylpiperidin-4-yl) 2-hydroxy-3-methyl-2-phenylbutanoate;
CAS Number	75321-25-4 ;
PubChem CID	21150216;
ChemSpider	20085385;
UNII	EA-3834;
CompTox Dashboard (EPA)	DTXSID101028494 ;
Chemical and physical data
Formula	C17H25NO3
Molar mass	291.391 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1CN(C)CCC1OC(=O)C(O)(C(C)C)c2ccccc2;
	InChI InChI=1S/C17H25NO3/c1-13(2)17(20,14-7-5-4-6-8-14)16(19)21-15-9-11-18(3)12-10-15/h4-8,13,15,20H,9-12H2,1-3H3; Key:IFXNWEDGILPSBA-UHFFFAOYSA-N;
	(verify)

EA-3834 is a potent anticholinergic deliriant drug with a fairly long duration of action, related to the chemical warfare agent 3-quinuclidinyl benzilate (QNB). It was developed under contract to Edgewood Arsenal during the 1960s as part of the US military chemical weapons program, during research to improve upon the properties of earlier agents such as QNB.

EA-3834 has a potency and central to peripheral effects ratio only slightly less than that of related compounds such as EA-3443, and is faster acting and shorter lasting, although not as much as other compounds such as 302196.^[1]^[2]

EA-3834 appears to cause renal problems, among them, microhematuria.^[3]

References

^ Commission on Life Sciences (1982). "N-Methyl-4-piperidinyl-(phenylisopropyl)-glycolate (EA 3834)". Possible Long-Term Health Effects of Short-Term Exposure to Chemical Agents. Vol. 1. The National Academies Press. pp. 200–204. doi:10.17226/740. ISBN 978-0-309-07759-0. PMID 25032448.
^ Ketchum JS (2006). Chemical Warfare Secrets Almost Forgotten. A Personal Story of Medical Testing of Army Volunteers with Incapacitating Chemical Agents During the Cold War. ChemBooks Inc. ISBN 978-1-4243-0080-8.
^ Khatchadourian, Raffi (December 9, 2012). "Operation Delirium". newyorker.com. Retrieved May 18, 2021. Another version [of BZ], called EA 3834, appeared to cause microscopic hematuria—tiny amounts of blood in urine—and other renal problems.

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[1] Commission on Life Sciences (1982). "N-Methyl-4-piperidinyl-(phenylisopropyl)-glycolate (EA 3834)". Possible Long-Term Health Effects of Short-Term Exposure to Chemical Agents. Vol. 1. The National Academies Press. pp. 200–204. doi:10.17226/740. ISBN 978-0-309-07759-0. PMID 25032448.

[Ketchum2006-2] Ketchum JS (2006). Chemical Warfare Secrets Almost Forgotten. A Personal Story of Medical Testing of Army Volunteers with Incapacitating Chemical Agents During the Cold War. ChemBooks Inc. ISBN 978-1-4243-0080-8.

[3] Khatchadourian, Raffi (December 9, 2012). "Operation Delirium". newyorker.com. Retrieved May 18, 2021. Another version [of BZ], called EA 3834, appeared to cause microscopic hematuria—tiny amounts of blood in urine—and other renal problems.

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[2]

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See also

References